Energetic view of metabolic pathways

Metabolism of living cells is a complex network of chemical reactions to extract, convert and store energy from nutrients that can be analyzed in self-contained parts called pathways. Metabolic pathways contribute to catabolism – the oxidative degradation of complex molecules to simpler compounds, and – the reductive synthesis of complicated molecules from simpler ones. Catabolic pathways release free energy some of which is conserved in the formation of adenosine triphosphate (ATP) and reduced pyridine nucleotides (NADH, NADPH).

Anabolic reactions require the input of energy, generally in the form of the free energy of hydrolysis of ATP and the reducing power of NADH and NADPH. The set of adenine and pyridine nucleotides constitutes a generalized cell energy status and determines rates of major metabolic fluxes. As the result, fluxes of energy and information become organized spatially, providing conditions for self-maitenance of metabolism.

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Source: www.mosbio.eu

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