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Dr. Natallia Kulik, PhD.
Position
Zámek 136, CZ 373 33 Nové Hrady
Phone: +420 389 033 822
kulik@nh.cas.cz
Past Projects
2000 - 2005 – Belarussian National Technical University (Faculty of Natural Resources and Ecology),Minsk, Belarus, degree – Ing.
2006 - 2011 – Doctoral study at the University of South Bohemia (Institute of Physical Biology), Nove Hrady, Czech Republic. Supervisor Prof. R. Ettrich. Ph.D in biophysics, thesis “Modeling substrate enzyme interactions in fungal hydrolases”
Employment:
2007 - 2011 - Researcher assistant, University of South Bohemia in Ceske Budejovice, Faculty of Sciences, Branisovska 31a, 370 05 Ceske Budejovice
2007 - 2011 - Research assistant, Institute of Nanobiology and Structural Biology, Academy of Sciences of the Czech Republic, Zamek 136, 373 33 Nove Hrady
2011 - 2015 - junior researcher, Institute of Nanobiology and Structural Biology, Academy of Sciences of the Czech Republic, Zamek 136, 373 33 Nove Hrady
2016 - now - junior researcher, Institute of Microbiology, Academy of Sciences of the Czech Republic, Zamek 136, 373 33 Nove Hrady
Experience abroad:
2011 – 2 week stay in Princeton University in the J. Carey lab (USA), work on the project “Parameterization and docking of quinones with a long tail in the active site of WrbA”
Running research projects:
“Theoretical Study of Photosynthetic Processes in Photosystem II ” in association with D. Reha (Czech Republic, Nove Hrady) and M. Kuty (Czech Republic, Ceske Budejovice).
Activity in the field of study:
Theoretical study of protein structures, substrate/inhibitor – enzyme interaction, analysis of structure function relationship in a wide range of enzymes (hyrolases, nitrilases), stimulation of proteins in lipids. Parameterization of cofactors and lipids for Amber force field. Wide experience with homology modeling, phylogenetic analysis, molecular dynamics simulation of systems and molecular docking.
Institute publications in impacted journals
- N. Kulik, M. Kutý, D. Řeha (2020) The study of conformational changes in photosystem II during a charge separation. In: Journal of Molecular Modeling. Vol Issue 26, pp. 1-13.
- Cecilia Garcia-Oliva, Pilar Hoyos, Lucie Petrásková, Natalia Kulik , Helena Pelantová, Alfredo H. Cabanillas, Ángel Rumbero, Vladimír Křen, María J. Hernáiz, and Pavla Bojarová (2019) Acceptor Specificity of beta-N-Acetylhexosaminidase from Talaromyces flavus: A Rational Explanation. In: International Journal of Molecular Sciences. Vol 20 (24)
- Lenka Rucká, Martin Chmátal, Natalia Kulik, Lucie Petrásková, Helena Pelantová, Petr Novotný, Romana Příhodová, Miroslav Pátek, and Ludmila Martínková (2019) Genetic and Functional Diversity of Nitrilases in Agaricomycotina. In: International Journal of Molecular Sciences. Vol 20 (23)
- Natallia Kulik, Kristyna Slamova, Rudiger Ettrich, Vladimir Kren (2015) Computational study of β-N-acetylhexosaminidase from Talaromyces flavus, a glycosidase with high substrate flexibility. In: BMC Bioinformatics. Vol 1 (16), pp. 28-.
- Slamova, Kristyna; Krejzova, Jana; Marhol, Petr; Kalachova, Lubica; Kulik, Natallia; Pelantova, Helena; Cvacka, Josef; Kren, Vladimir (2015) Synthesis of Derivatized Chitooligomers using Transglycosidases Engineered from the Fungal GH20 beta-N-Acetylhexosaminidase. In: ADVANCED SYNTHESIS & CATALYSIS . Vol 8 (357), pp. 1941-1950.
- Kristýna Slámová, Natallia Kulik, Martin Fiala, Jana Krejzová-Hofmeisterová, Rüdiger Ettrich, Vladimír Křen (2014) Expression, characterization and homology modeling of a novel eukaryotic GH84 β-N-acetylglucosaminidase from Penicillium chrysogenum. In: rotein Expression and Purification. Vol 95, pp. 204-210.
- Jana Krejzová, Kristýna Slámová, Petr Šimona, Lubica Kalachova, Natallia Kulik, Pavla Bojarová, Petr Marhol, Helena Pelantová, Josef Cvačka, Rüdiger Ettrich, Vladimír Křen (2014) Inhibition of GlcNAc-processing glycosidases by C-6-azido-NAG-thiazoline and its derivatives. In: Molecules. (19), pp. 3471-3488.
